Tissue Factor Pathway Inhibitor (TFPI) (Last Updated - 2/26/2005)
-or Extrinsic Pathway Inhibitor
-found in lipoproteins
-binds to:
A) Factor Xa --> Inhibits it
B) Factor VIIa/Tissue Factor-complex --> Inhibits it
-release is induced w/ high doses of Heparin
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References:
Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.